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Replacement of the list of 23 steroids with a list of 59 steroids, including both intrinsically active steroids as well as steroid metabolic precursors, was achieved by using a method described by the manufacturer of the original testosterone supplement. The method is described in detail in the present invention. The method takes advantage of a combination of the presence of a steroid and a natural stimulant that causes the levels of free testosterone and free estradiol, respectively, to decrease in a subject. A specific type of stimulant that produces a reduction in levels of the steroid and a normal or anionic environment for the free testosterone and free estradiol is preferred. The stimulant consists of phenylalanine or a highly specific anion for the free testosterone or free estradiol and an aqueous solution that is in excess of 15 ml. An additional advantage of the method is that the free testosterone can be measured in a separate analytical system, as opposed to the method described above, where it is measured under the influence of a drug of the same name. By using this method and administering either 5 mg of testosterone enanthate or testosterone propionate daily to the subject, the level of free testosterone and free estradiol of the subject can be measured over a 24hr testicular cycle. The method also employs a single administration of an aqueous solution of 5.4 g/kg of testosterone propionate or 5.4 g/kg of testosterone enanthate. A 5.4 g/kg dose of testosterone enanthate produces a 50% reduction in free testosterone levels from placebo whereas a 5.4 g/kg dose of testosterone propionate provides a reduction of 0% in free testosterone levels from placebo. By contrast, 5.4 g/kg of the anion-containing formulations of testosterone propionate and 5.4 g/kg of the anionic testosterone do not reduce free testosterone levels. However, because the anionic formulation of 5.4 g/kg of the pure-anion formulation is so stable and has fewer side effects than the pure-anion formulation, this method does not require the use of a preservative in the preparation. Because the anion formulation of 5.4 g/kg of pure-anion testosterone provides the greatest degree of stability and is relatively simple to prepare, this formulation is often used to administer testosterone enanthate to test subjects. By contrast, pure-anion testosterone has been used with no appreciable side effects for a number of years as an alternative to 5.4 g/kg of pure-anion. Thus, an approach that Similar articles:


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